Context: Research studies increasingly respond to a broad range of stakeholders interested in generalizable as well as rigorously evaluated outcomes, focused on what is effective in the field. Methods to conduct patient-centered outcomes (PCOR) and comparative effectiveness research (CER) may include new partners on the research team: patients and their clinicians. PCOR stakeholder-engaged research brings members of the target community directly into the team to be equal, collaborative members in planning, designing, implementing, and disseminating the research. A current, five-year pragmatic, patient centered outcomes and comparative effectiveness research study on Integrating Behavioral Health and Primary Care (IBH-PC) asked its stakeholders – patients, clinicians, payers, and policy makers – to develop a guide for patient partner engagement in practice quality improvement as a part of its intervention. Objective: Adapt the IBH-PC study intervention guide for a new purpose: establish a generalizable method of building stakeholder engagement capacity in PCOR and CER. Project Design: We used a team-based, iterative, and adaptive process that is based on tools in the IBH-PC guide. We collaborated with new stakeholders in co-creating a tested protocol of activities that effectively foster reciprocal relationships between researchers and stakeholders in team-based PCOR and CER. Setting: This development process took place entirely on a web-based and virtual learning forum supporting synchronous and asynchronous communication. Population: Primary care patients, family members, healthcare team members, and researchers from the multiple chronic conditions (MCC) community as well as other stakeholders. This population includes collaborators from an advisory group of the IBH-PC study, members from other patient-based forums, doctoral students studying integrated behavioral health, and patients and clinicians from the IBH-PC study who elect to participate. Total number of participants expected is 65 out of a pool of over 3,000. Outcomes to be reported: An initial version of The Partnering Guide for PCOR and the tools for capacity building, including self-assessment of needs, tested engagement activities, and the web-based platform. These initial tools will continue to be tested and revised to support PCOR and CER capacity building in a PCORI funded project in 2021.