Context: The COVID-19 pandemic is a major challenge for patients acquiring COVID-19, their families, and our healthcare system. Almost 95% of individuals testing positive for COVID-19 in Quebec, Canada are self-isolating at home with limited access to medical resources in case of worsening symptoms. Guiding patients in the monitoring of their symptoms and vital signs and, connecting them with a healthcare team may significantly reassure them, while ensuring a timelier follow-up. The mobile health application Opal was thus quickly adapted to the COVID-19 situation. Objective: To examine the feasibility of implementing the Opal app for COVID-19. Study Design: Three-month survey-based pilot study. Setting/Population: Fifty COVID-19 adult positive-testers at the McGill University Health Centre, Montreal, Canada who are prescribed self-isolation at home. Intervention: A minimum 14-day intervention involving: 1) Daily patient-reported self-assessment of physical and mental health (e. g. , symptoms, vital signs) captured in the application to allow remote follow-up by a multidisciplinary team including nurses, physicians, and a psychiatrist; 2) Needs-based timely support or teleconsultations for patients with worsening symptoms/clinical status in relation to COVID-19 or psychological distress; 3) Educational material for patients via the application to facilitate self-management. Outcome measures: Data will be collected with validated instruments as well as measures created for this study. Feasibility will be primarily assessed in relation to targets for recruitment, retention, fidelity (i. e. completion of the daily self-assessments) as well as perceived acceptability, response burden, usability of the intervention, and patient satisfaction with teleconsultations. Anticipated results: With recruitment beginning in June, results are expected in August 2020. It is anticipated that the intervention will be feasible and acceptable for monitoring self-isolated COVID-19 patients and deliver timely care when needed. This study could provide data to inform implementation in other sites, to support remote follow-up, and to acquire essential knowledge about the disease course among non-hospitalized patients. By offering a “one-stop destination” for self-monitoring, education, and tailored care, the adaptation of Opal has great potential for future outbreaks and other conditions or situations necessitating remote follow-up.