Context: Despite significant investment, in the UK, health inequalities continue to worsen; this is particularly true for multimorbidity which is socially patterned. There are several recognised individual factors that impact on patients’ capacity to manage the work associated with multimorbidity, many of which cluster in areas experiencing socioeconomic deprivation. The extent, and impact, of community level factors is not understood. Understanding these factors is critical if we are to design interventions and services that narrow rather than widen health inequalities. Objectives: to explore, and start to quantify the impact of, key factors impacting capacity to self-manage multimorbidity in the context of socio-economic deprivation, and how individual and community level factors interact to influence health management decisions. Study design: mixed methods study comprising three work packages. Work package 1(WP1): Systematic Review with qualitative synthesis of patient experience of current multimorbidity interventions, and exploration of how self-management, treatment burden, capacity and socio-economic deprivation are targeted, if at all. Work package 2(WP2): an ethnography in a community experiencing high socio-economic deprivation (in Scotland) will explore individual and community factors influencing patient capacity and how they interact to influence health management decisions. This work will also consider how the coronavirus, and lockdown, have impacted community resource and capacity. Work package 3(WP3): Quantitative analysis, using data from the West of Scotland Twenty-07 cohort, of the impact of individual and community factors on mortality, self-reported health and healthcare utilisation. Expected outcomes: Knowledge of patient experience of multimorbidity interventions and the extent to which self-management, patient workload, capacity and socio-economic deprivation are targeted in multimorbidity interventions. An in-depth understanding of how individual and community level factors impact patients’ ability to self-manage multimorbidity. An understanding of how community beliefs and resources enhance, or limit, capacity at an individual level. How community and individual capacity have been impacted by coronavirus. Quantification of the impact, if any, of individual or community factors on mortality, self-reported health and healthcare utilisation