PRP027: Association of Birth Weight with the Incidence of Chronic Diseases in Adulthood: A longitudinal Population-Based Study
Tamim Rajjo, MD, MPH, MD. MPH; Antonela Miccoli; Thomas Thacher, MD; Julie Maxson, CCRP; Tara Kaufman, MD; Brian Lynch, MD; Teresa Jensen, MD; Seema Kumar, MD
The prevalence of obesity continues to rise and its direct association with multiple co-morbidities has substantial effect on disease outcomes and increased health care spending. Pathogenesis of obesity is multifactorial but some risk factors have been associated with maternal health during pregnancy. Recent longitudinal studies has shown that small for gestational age newborns are at a higher risk of mortality compared to normal or large for gestational age newborns. The primary aim of this study is to investigate the relationship between birth weight for gestational age and weight gain trajectories in early childhood and long term incidence of multiple chronic conditions including cardiometabolic disease risk factors (as Types 1 & 2 diabetes mellitus, hypertension, adult obesity, and hyperlipidemia), Asthma and Polycystic ovarian Syndrom.
Population-based, retrospective birth cohort study. The birth cohort consists of all children born between January 1, 1976, and December 31, 1982, to mothers in Olmsted County, MN. The target population will be children with available follow up anthropometric and outcome information in the Rochester Epidemiology Project (REP) through 6/31/2019 or until death or migration from the community.
We will be extracting birth weight status as well as weight gain trajectories for included subjects with incidence of certain chronic diseases in that cohort. Birth information will be obtained from birth certificates and all other variables will be extracted from the Rochester Epidemiology Project tool with appropriate consents.
The cohort of interest initially consisted of 10938 children. After applying exclusion criteria the total number of subjects is 7892. We will be working with a REP statistician to estimate primary and secondary end points. Growth trajectories will be determined for those with a minimum of 3 measures between ages 0 and 5.5 years. The Cumulative Incidence of different chronic diseases in this cohort by age 30 year are as follows: Hypertension 3.1%, Hyperlipidemia 4.2%, Types 1&2 Diabetes: 1.9%, Asthma 18.0%, PCOS 2.4% (among 4839 females).
Based on final results we will be concluding whether birth weight status and/or elevated BMI trajectory persisting from birth through childhood and adolescence result in an unfavorable cardiometabolic risk profile in during that time and through adulthood.