Context: Hospitalizations are costly and risky, especially for vulnerable patients with chronic illness. Several systematic reviews have looked at Hospital-at-Home (HaH) interventions and suggest that it may reduce the risks associated with hospitalization and improve patient outcomes. However, results for patient outcomes remain inconsistent according to a recent meta-review, which looked at HaH reviews of various populations. Objective: To assess the effectiveness of HaH when considering patient outcomes for persons with all types of chronic illnesses who present to the emergency department. Design: Systematic review with meta-analysis and narrative analysis. Setting: The following databases were searched: OVID MEDLINE, OVID EMBASE, OVID PsycINFO, CINAHL (EBSCOhost), HTA (Centre for Reviews and Dissemination), Cochrane Reviews and CENTRAL Trials (Cochrane Library), OVID Allied and Complementary Medicine Database (AMED), WHO International Clinical Trials Registry Platform (ICTRP), and ClinicalTrials.gov. Main and Secondary Outcome Measures: Pooled risk ratio and mean difference for mortality, subsequent hospital admissions, and length of treatment. Descriptive analysis for outcomes that are either only reported by one study or measured in two or more studies using different tools, for which we cannot find evidence of comparability. Results: Preliminary results show that mortality does not differ between HaH and in-hospital care (RR 0.84, 95%CI 0.61, 1.16) and subsequent hospital admissions is slightly lower with HaH (RR 0.73, 95%CI 0.57, 0.94). Conclusions: HaH shows potential to improve patient outcomes and be equally as safe as in-hospital care for persons with all types of chronic illnesses presenting to the emergency department.